KPV is a synthetic tripeptide (lysine-proline-valine) corresponding to the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). It is widely used as a research tool in inflammation and gut-barrier models.
What Is KPV?
KPV represents the final three amino acids of alpha-MSH. Research interest centers on whether this short fragment retains the anti-inflammatory-associated activity studied in the parent hormone, without the pigmentation-related activity of full-length alpha-MSH.
How KPV Is Studied
In published preclinical literature, KPV has been investigated for its relationship to the NF-κB signaling pathway, modulation of pro-inflammatory cytokines, and intestinal epithelial transport via the PepT1 transporter. It is frequently used as a model compound in colitis and mucosal-barrier research.
Related Research Reading
KPV is often studied alongside copper peptides such as GHK-Cu in tissue and recovery research. Browse the full healing and recovery research category.
Handling and Reconstitution
Lyophilized KPV is typically kept refrigerated and protected from light for short-term handling and frozen for longer-term storage. See our reconstitution guide.
Frequently Asked Questions
What is KPV studied for?
KPV is studied as a tool compound in inflammation and gut-barrier research, particularly in relation to the NF-κB pathway and PepT1 transport.
How is KPV related to alpha-MSH?
KPV is the C-terminal tripeptide fragment of alpha-MSH and is studied for the anti-inflammatory-associated activity attributed to that region.
Where can I find KPV for research?
Greatest Peptides supplies KPV 10 mg at 99%+ purity with a batch-specific COA, for laboratory research use only.
All compounds referenced here are sold strictly for laboratory and research use only. They are not dietary supplements, drugs, or therapeutic products, and nothing here describes effects in humans.